Resources

Clinical Trials

CURRENTLY RECRUITING! Newly Opened Brain Cancer Phase 2 Clinical Trial (2022): https://www.mimivax.com/roswell-park-opens-phase-2b-randomized-clinical-trial-of-promising-brain-cancer-immunotherapy/

CURRENTLY RECRUITING! SONODYNAMIC THERAPY – RECURRENT HIGH-GRADE GLIOMA   Ivy brain Tumor Center (2022).

ACTIVE, Not Currently Recruiting. (This is trial Harry Lorusso did.) Sidney Kimmel Comprehensive Cancer Center at John Hopkins: GMCI, Nivolumab, and Radiation in Treating Newly Diagnosed High-Grade Gliomas,

CURRENTLY RECRUITING! National Cancer Institute- Testing the Addition of Immune Therapy Drugs,

CURRENTLY RECRUITING! OncoSynergy Inc. and Moffit Cancer Center- Recurrent Glioblastoma,

CURRENTLY RECRUITING! Hillman Cancer Center- Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM (https://clinicaltrials.gov/ct2/show/NCT01811498),

Gamma Knife Radiation Clinical Outcomes (https://clinicaltrials.gov/ct2/show/NCT01811498),

Mayo Clinic Gamma Knife

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.
Shireman JM, Atashi F, Lee G, Ali ES, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS, James CD, Stupp R, Kumthekar P, Horbinski CM, Ben-Sahra I, Ahmed AU
Brain. 2021 May; 144(4): 1230-1246.
https://doi.org/10.1093/brain/awab020
PMID: 33855339
A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.
Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R, Lukas RV, Jovanovic B, McCortney K, Colman H, Chen S, Lai B, Antipova O, Deng J, Li L, Tommasini-Ghelfi S, Hurley LA, Unruh D, Sharma NV, Kandpal M, Kouri FM, Davuluri RV, Brat DJ, Muzzio M, Glass M, Vijayakumar V, Heidel J, Giles FJ, Adams AK, James CD, Woloschak GE, Horbinski C, Stegh AH
Sci Transl Med. 2021 Mar; 13(584):
https://doi.org/10.1126/scitranslmed.abb3945
PMID: 33692132
Articles:

(2022) International Brain Tumor Alliance Magazine- Re-thinking Brain Tumor Drug Development

New York Post (9/20), 5ALA Imaging Dye,
What is the Blood Brain Barrier? (article resource Brains for the Cure),

UNC School of Medicine-Optune Device, Optune–Clinical Study Results,

Gamma Knife Fact Sheet–Yale University,

Novocure chief scientist explains how company’s electronic headgear offers hope to brain tumor patients (article resource Brains for the Cure),

The Power of Positive Thinking–Johns Hopkins ,

How COVID-19 Impacts Cancer Care and Research,

It’s time to invite more people to join clinical trials,

Deciding whether to be part of a clinical trial

Flipping the Switch: A National Cancer Institute Interview with Dr. Mark Gilbert (article),
The Science of Social Connection: An article by Dr. Emma Seppala of Stanford University (article)
Online Resources:

Books:
Ep. 5: A Night Without Armour: Poems by Jewel

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