GAME ON GLIO NEWS
Repurposing approved non-antitumor drugs is a promising and affordable strategy in drug discovery to identify new therapeutic uses different from the original medical indication that may help increase the number of possible, effective anticancer drugs
Mebendazole can penetrate the blood-brain barrier and has been shown to inhibit the malignant progression of glioma by targeting signaling pathways related to cell proliferation, apoptosis, or invasion/migration, or by increasing the sensitivity of glioma cells to conventional chemotherapy or radiotherapy.
Mebendazole might be an excellent candidate for the treatment of brain tumors because of its efficacy both when used as monotherapy and in combination as an enhancement to standard chemotherapeutics and radiotherapy, due to its effectiveness on tumor angiogenesis inhibition, cell cycle arrest, apoptosis induction, and targeting of critical pathways involved in cancer such as Hedgehog signaling.
Learn more about this study at National Library of Medicine.
CURRENTLY RECRUITING! Imvax Inc. IGV-001- Phase 2b Clinical Trial Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma,
CURRENTLY RECRUITING! Hillman Cancer Center- Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations,
CURRENTLY RECRUITING! Roswell Cancer Center- SurVaxM Vaccine-Brain Cancer Immunotherapy,
Locations for the SurVaxM Vaccine recruitment include: Roswell Park Cancer Center, NYU Langone, Dana-Farber Cancer Institute, Overlook Medical Center, Norton Cancer Institute Brownsboro, Baptist Health Miami Cancer Institute, Texas Oncology-Austin Brain Tumor Center, Fred Hutchinson Cancer Center,
UCSF Brain Tumor Center
CURRENTLY RECRUITING! Ivy Brain Tumor Center- INFIGRATINIB IN RECURRENT GLIOBLASTOMA PATIENTS (phase 0 trial),
CURRENTLY RECRUITING! Ivy Brain Tumor Center- Phase 0 Clinical Trial for Recurrent Glioblastoma,
CURRENTLY RECRUITING! Lenox Hill/Northwell Health- Tissue autograft to bypass the blood brain barrier (BBB) in human glioblastoma multiforme,
CURRENTLY RECRUITING! University of California San Francisco- A New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT (ages 3-30)
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