Ep. 12: “From Bench to Bedside: Talking Pediatric Brain Cancer” with Guests Dr. Lindsey Hoffman & Dr. Adam Green

Ep. 12: “From Bench to Bedside: Talking Pediatric Brain Cancer”-with Dr. Lindsey Hoffman & Dr. Adam Green 


            It’s hard to imagine that children can get the same cancers adults get. It’s hard to imagine children get cancer at all. The unfortunate truth is, children do get cancer–even brain cancer; between 200-500 children are diagnosed each year in the U.S. So, what is being done to help these beautiful little beings? A lot! Dr. Lindsey Hoffman, with Phoenix Children’s Hospital, and Dr. Adam Green with Children’s Hospital Colorado are both leading the charge in treatment of pediatric brain cancers.

Dr. Hoffman serves as Director of the Neuro-Oncology and Cancer Predisposition Programs in the Center for Cancer and Blood Disorders at Phoenix Children’s Hospital in Phoenix, Arizona. A board certified Pediatrics and Pediatric Hematology/Oncologist, she is also trained in Pediatric Neuro-Oncology. Dr. Hoffman’s research interests include exploration of genetic and other biological drivers of pediatric central nervous system tumors. She was recently appointed Chair of the International Diffuse Intrinsic Pontine Glioma Registry, a data and tissue repository of more than 1,100 cases of DIPG, a rare and notoriously lethal pediatric brain tumor. The DIPG Registry serves as a resource for the broader scientific community to support research initiatives that aim to better understand and treat DIPG.

Adam Green, MD, is an Associate Professor of Pediatrics at the University of Colorado School of Medicine and an attending pediatric neuro-oncologist at Children’s Hospital Colorado. He served as a resident and chief resident in pediatrics at the University of Colorado and as a pediatric hematology-oncology fellow at Dana-Farber Cancer Institute and Boston Children’s Hospital. There, he trained in translational research in pediatric brain tumors with Drs. Andrew Kung and Stu Orkin. His lab investigates novel targets and therapeutic strategies in the treatment of pediatric high-grade glioma (HGG). There are several clinical trials currently open or in development based on work from his lab.

Resources from Ep. 12:


National Library of Medicine, Green, AL.- Pediatric high-grade glioma: moving toward subtype-specific multimodal therapy, 

High-Grade Gliom Study, Green, AL.- BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway,

Pediatric Cancer Trial of Optune Device at Hackensack Meridian Children’s Health- Pediatric Cancer Trial of Optune Device,

PubMed, National Library of Medicine: Tumor-Treating Fields Therapy for Pediatric Brain Tumors,

PubMed, National Library of Medicine, Lindsey M Hoffman- Targeted fusion analysis can aid in classification and treatment of pediatric glioma


Pediatric Brain Tumor Story:

For more resources, visit our resource page here.

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